UToledo Biofluidics Lab

Publications

Papers:

  1. Malla S, Nyinawabera A, Neupane R, Pathak R, Lee D, Abou-Dahech M, Kumari S, Sinha S, Tang Y, Ray A, Ashby CR Jr, Yang MQ, Babu RJ, Tiwari AK. Novel Thienopyrimidine-Hydrazinyl Compounds Induce DRP1-Mediated Non-Apoptotic Cell Death in Triple-Negative Breast Cancer Cells. Cancers (Basel). 2024 Jul 23;16(15):2621. doi: 10.3390/cancers16152621. PMID: 39123351; PMCID: PMC11311031.

  2. Ghaedamini H, Khalaf K, Kim DS, Tang Y. A novel ACE2-Based electrochemical biosensor for sensitive detection of SARS-CoV-2. Anal Biochem. 2024;689:115504. Epub 20240306. doi: 10.1016/j.ab.2024.115504. PubMed PMID: 38458306.

  3. Sigdel I, Ofori-Kwafo A, Heizelman RJ 3rd, Nestor-Kalinoski A, Prabhakarpandian B, Tiwari AK, Tang Y. Biomimetic on-chip assay reveals the anti-metastatic potential of a novel thienopyrimidine compound in triple-negative breast cancer cell lines. Front Bioeng Biotechnol. 2023;11:1227119. doi: 10.3389/fbioe.2023.1227119. eCollection 2023. PubMed PMID: 37840664; PubMed Central PMCID: PMC10569307.

  4. Fernandez-Fernandez A, Manchanda R, Cunha Rodrigues JM, Tang Y. Editorial: State-of-the-art rational nanodesign: from screening to theranostics and from bench to clinic. Front Pharmacol. 2023;14:1210185. doi: 10.3389/fphar.2023.1210185. eCollection 2023. PubMed PMID: 37266141; PubMed Central PMCID: PMC10230074.

  5. Khare VM, Saxena VK, Pasternak MA, Nyinawabera A, Singh KB, Ashby CR Jr, Tiwari AK, Tang Y. The expression profiles of chemokines, innate immune and apoptotic genes in tumors caused by Rous Sarcoma Virus (RSV-A) in chickens. Genes Immun. 2022 Feb;23(1):12-22. doi: 10.1038/s41435-021-00158-0. Epub 2021 Dec 21. PubMed PMID: 34934184.

  6. Yang Q, Langston JC, Tang Y, Prabhakarpandian B, Kilpatrick LE, Kiani MF. A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation. J Vis Exp. 2021 Dec 9;(178). doi: 10.3791/63312. PubMed PMID: 34958086.

  7. Sigdel I, Gupta N, Faizee F, Khare VM, Tiwari AK, Tang Y. Biomimetic Microfluidic Platforms for the Assessment of Breast Cancer Metastasis Front Bioeng Biotechnol. 2021;9:633671. doi: 10.3389/fbioe.2021.633671. eCollection 2021. Review. PubMed PMID: 33777909; PubMed Central PMCID: PMC7992012.

  8. Soroush F, Tang Y, Mustafa O, Sun S, Yang Q, Kilpatrick LE, Kiani MF.Neutrophil-endothelial interactions of murine cells is not a good predictor of their interactions in human cells. FASEB J. 2020 Feb;34(2):2691-2702. doi: 10.1096/fj.201900048R. Epub 2019 Dec 23. PubMed PMID: 31908006; PubMed Central PMCID: PMC7018548.

Presentations:

  1. Sigdel, I.*, Ofori-Kwafo, A., Khalaf, K., Nestor-Kalinoski, A., Tiwari, A.K., and Tang, Y. A novel non-apoptotic compound prevents breast cancer intravasation by protecting endothelial cells in a microfluidic model. Biomedical Engineering Society annual meeting; 2023 Oct. Seattle, WA. 

  2. Ofori-Kwafo, A.*, Sigdel, I., Zubcevic, J., and Tang, Y. Establishing a tri-culture model to study the interactions of the gut brain axis on a microfluidic device. Biomedical Engineering Society annual meeting; 2023 Oct. Seattle, WA. 

  3. Sigdel, I.*, Ofori-Kwafo, A., Heizelman, R.J., III, Tiwari, A.K., Tang, Y. Biomimetic On-Chip Assay Reveals the Anti-Metastatic Potential of a Novel Compound Via Non-Apoptotic Cancer-Killing. Biomedical Engineering Society annual meeting; 2022 Oct. San Antonio, TX.  

  4. Ofori-Kwafo, A.*, Sigdel, I., Heizelman, R.J., III, Tiwari, A.K., Tang, Y. Microvasculature-on-a-Chip for Studying Endothelial Cell Pathophysiology. Biomedical Engineering Society annual meeting; 2022 Oct. San Antonio, TX. 

  5. Tang, Y.*, Sigdel, I., Ofori-Kwafo, A., Heizelman, R., Vogel, P., Tiwari, A.K. A novel biomimetic microfluidic platform for the study of breast cancer metastasis.  Dominican Week of Science and Technology / XVII INTERNATIONAL CONGRESS OFSCIENTIFIC RESEARCH (XVII CIC); 2022 Jun. Santo Domingo, Dominican Republic.   

  6. Sigdel, I., Ofori-Kwafo, A., Tiwari, A.K., Tang, Y.*  Microvasculature-on-a-Chip for Studying Endothelial Cell Pathophysiology. American Institute of Chemical Engineers annual meeting; 2021 Nov. Boston, Massachusetts.  

    7. Posters:

    1. Khalaf, K., Ghaedamini, H., Sigdel, I., Ofori-Kwafo, A., Kim, D.S., and Tang, Y*. A Highly Selective COVID Detection System Utilizing Electrical Impedance and Electrode Technology. Biomedical Engineering Society annual meeting; 2023 Oct. Seattle, WA. 

    2. Ofori-Kwafo, A., Sigdel, I., Heizelman III, R. J., Tang, Y.
      Quantifying Breast Cancer Intravasation, Extravasation and Angiogenesis Using High Throughput Assays.
      Biomedical Engineering Society annual meeting;       2022 Oct. San Antonio, TX.

    3. Sigdel, I., Faizee, F., Ofori-Kwafo, A., Tiwari, A. K., Tang, Y.
      Preventing Breast Cancer Metastasis by Attenuating Chemotherapy-Induced Endothelial Inflammation.
      Biomedical Engineering Society annual meeting;       2021 Oct. Orlando, FL.